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Alternate Names: Tiamate, Tiazac, Aldizem
CAS No: 144604-00-2
PubChem CID: 3037122
Mol Formula: C26H32N2O9S
Mol Weight: 548.6 g/mol
IUPAC Name: [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate;(2S)-2-hydroxybutanedioic acid
Therapeutic use: Antihypertensives, Cardiovascular
Drug Class: Calcium Channel Blockers
API Description: Diltiazem Malate is a malate salt of diltazem, a benzothiazepine calcium channel blocking agent. Diltiazem inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells.
