Active Pharmaceutical Ingredients (APIs)

Ixazomib Citrate is a small molecule drug with a maximum clinical trial phase of IV (across all indications) that was first approved in 2015 and is indicated for multiple myeloma and has 14 investigational indications.

Levodropropizine is a peripheral antitussive agent used to suppress cough. It acts by inhibiting sensory nerve activation in the airways, providing relief from non-productive coughs.

Glucagon (synthetic) is a laboratory-produced version of the natural peptide hormone glucagon, which is normally secreted by the alpha cells of the pancreas. Synthetic glucagon is manufactured using solid-phase peptide synthesis or recombinant DNA technology, and it is commercially available as a generic medication if it demonstrates bioequivalence and therapeutic equivalence to the natural or recombinant forms. - Show More

Xanomeline is a Cholinergic Muscarinic Agonist. The mechanism of action of xanomeline is as a Cholinergic Muscarinic Agonist, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.

Vosoritide, sold under the brand name Voxzogo, is a medication used to improve linear growth in children with achondroplasia, a genetic condition causing short stature. It's a recombinant C-type natriuretic peptide analogue, meaning it's a modified version of a natural peptide that helps regulate bone growth. Vosoritide works by binding to a specific receptor on cartilage cells, promoting growth by inhibiting pathways that restrict bone development. - Show More

Daprodustat is a member of the class of barbiturates that is barbituric acid substituted by cyclohexyl groups at positions 1 and 3, and by a (carboxymethyl)aminocarbonyl group at position 5. It is an inhibitor of hypoxia-inducible factor prolyl hydroxylase developed by GlaxoSmithKline for the treatment of anaemia in patients with chronic kidney disease. It has a role as an anti-anaemic agent, an EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor and an antiviral agent. It is a member of barbiturates, a secondary carboxamide, a N-acylglycine and an oxo monocarboxylic acid. - Show More

Cefoperazone Sodium is the sodium salt form of cefoperazone and a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefoperazone sodium inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis. - Show More

Irinotecan is a topoisomerase inhibitor used for chemotherapy. It is a water-soluble analogue of [camptothecin], which is extracted from the Chinese tree Camptotheca acuminate. The bis-piperidine side chain in the structure of irinotecan bestows enhanced water solubility. As an anticancer drug, irinotecan was first commercially available in Japan in 1994 to treat various cancers such as lung, cervical and ovarian cancer. Approved by the FDA in 1996, irinotecan is used to treat colorectal cancer and pancreatic adenocarcinoma. Irinotecan liposome was approved by the FDA in February 2024. The active metabolite SN-38 is also a potent inhibitor of DNA topoisomerase I. Both irinotecan and SN-38 mediate antitumor activity by forming a complex with topoisomerase I and blocking its enzymatic activity, thereby interfering with DNA synthesis. This leads to the arrest of the cell cycle in the S-G2 phase and cancer cell death. - Show More

Etonogestrel is a 17beta-hydroxy steroid, a 3-oxo-Delta(4) steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a female contraceptive drug. Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. - Show More

Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evidence that pregabalin exerts its effects by binding to the α2δ subunit of voltage-dependent calcium channels. Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release). It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders. - Show More