Welcome to apicule’s comprehensive list of Active Pharmaceutical Ingredients (APIs) also known as drug substances. Here, you’ll find detailed information about the most sought-after APIs used across the pharmaceutical industry. Each entry provides insights into the chemical properties, applications, and trusted manufacturers or distributors, making it easier for businesses to make informed decisions. Whether you’re sourcing for production, research, or distribution, our meticulously curated list is designed to cater to all your requirements. Explore the possibilities below and discover the right solutions for your pharmaceutical needs.
Fosinopril is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and heart failure. Fosinopril is associated with a low rate of transient serum aminotransferase elevations during therapy and has been linked to rare instances of acute liver injury. - Show More
Lomefloxacin is a fluoroquinolone antibiotic used to treat bacterial infections by inhibiting DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication.
Mesalazine is an anti-inflammatory drug used to treat inflammatory bowel diseases such as ulcerative colitis and Crohn's disease. It works locally in the gut to reduce inflammation.
Oxymetazoline Hydrochloride is the hydrochloride salt form of oxymetazoline, an imidazole derivative with a direct acting sympathomimetic property. Oxymetazoline binds to and activates alpha-2 adrenergic receptors. Upon nasal or ocular administration, oxymetazoline constricts the arterioles in the nose and eye, resulting in decreased nasal and conjunctival congestion, respectively. - Show More
Orforglipron is an oral, non-peptide, small-molecule GLP-1 receptor agonist being developed by Eli Lilly for the treatment of type 2 diabetes and obesity. It was discovered by Chugai Pharmaceutical and licensed to Lilly in 2018. Orforglipron is designed to be a once-daily oral medication, and clinical trials have shown promising results for both weight loss and HbA1c reduction in patients with type 2 diabetes and obesity. - Show More
Tirzepatide is a once-weekly injectable medication approved by the FDA for the treatment of type 2 diabetes, chronic weight management, and moderate-to-severe obstructive sleep apnea (OSA) in adults with obesity. It is marketed under the brand names Mounjaro (for diabetes) and Zepbound (for weight loss and OSA). - Show More
Daprodustat is a member of the class of barbiturates that is barbituric acid substituted by cyclohexyl groups at positions 1 and 3, and by a (carboxymethyl)aminocarbonyl group at position 5. It is an inhibitor of hypoxia-inducible factor prolyl hydroxylase developed by GlaxoSmithKline for the treatment of anaemia in patients with chronic kidney disease. It has a role as an anti-anaemic agent, an EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor and an antiviral agent. It is a member of barbiturates, a secondary carboxamide, a N-acylglycine and an oxo monocarboxylic acid. - Show More
Metformin is the most popular anti-diabetic drug in the United States and one of the most prescribed drugs in the country overall, with nearly 35 million prescriptions filled in 2006 for generic metformin alone. Metformin is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM). It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption and increasing insulin-mediated glucose uptake. Metformin is the only oral antihyperglycemic agent that is not associated with weight gain. Metformin may induce weight loss and is the drug of choice for obese NIDDM patients. When used alone, metformin does not cause hypoglycemia; however, it may potentiate the hypoglycemic effects of sulfonylureas and insulin. Its main side effects are dyspepsia, nausea and diarrhea. Dose titration and/or use of smaller divided doses may decrease side effects. Metformin should be avoided in those with severely compromised renal function (creatinine clearance < 30 ml/min), acute/decompensated heart failure, severe liver disease and for 48 hours after the use of iodinated contrast dyes due to the risk of lactic acidosis. Lower doses should be used in the elderly and those with decreased renal function. Metformin decreases fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Metformin may also have a positive effect on lipid levels. In 2012, a combination tablet of linagliptin plus metformin hydrochloride was marketed under the name Jentadueto for use in patients when treatment with both linagliptin and metformin is appropriate. - Show More
Atorvastatin is a dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases. It has a role as an environmental contaminant and a xenobiotic. It is an aromatic amide, a member of monofluorobenzenes, a statin (synthetic), a dihydroxy monocarboxylic acid and a member of pyrroles. It is functionally related to a heptanoic acid. It is a conjugate acid of an atorvastatin(1-). - Show More
Bupivacaine hydrochloride is a racemate composed of equimolar amounts of dextrobupivacaine hydrochloride and levobupivacaine hydrochloride. Bupivacaine Hydrochloride is a long-acting, amide-type local anesthetic. Bupivicaine reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation. - Show More
