Cyclooxygenase‑1 (COX‑1) inhibitors are mainly NSAIDs that block the COX‑1 enzyme, reducing prostaglandin synthesis for analgesic, antipyretic, and anti‑inflammatory effects, but at the cost of GI and renal safety because COX‑1 also mediates “housekeeping” prostaglandins. Here is a list of Cyclooxygenase‑1 (COX‑1) Inhibitor APIs.
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