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Alternate Names: Volasertibum, BI-6727
CAS No: 755038-65-4
PubChem CID: 10461508
Mol Formula: C34H50N8O3
Mol Weight: 618.8 g/mol
IUPAC Name: N-[4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-4-[[(7R)-7-ethyl-5-methyl-6-oxo-8-propan-2-yl-7H-pteridin-2-yl]amino]-3-methoxybenzamide
API Description: Volasertib is a cancer drug that works by inhibiting Polo-like kinase 1 (PLK1), a key cell-cycle regulator, primarily used in clinical trials for Acute Myeloid Leukemia (AML), especially in older patients unfit for intensive chemotherapy, often combined with low-dose cytarabine (LDAC) for higher remission rates. It also shows potential in solid tumors like cervical, colon, and lung cancers by causing cell death (apoptosis) and halting cell division. While promising, Volasertib is not yet FDA-approved for general use, with Phase III trials ongoing to confirm its efficacy in AML.
