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Alternate Names: Tivozanib hydrochloride anhydrous, Fotivda
CAS No: 682745-43-3
PubChem CID: 21079505
Mol Formula: C22H20Cl2N4O5
Mol Weight: 491.3 g/mol
IUPAC Name: 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea;hydrochloride
Drug Class: Kinase inhibitors, Tyrosine Kinase Inhibitors, VEGF inhibitors
Commercial / Development Status: Commercial APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: Tivozanib Hydrochloride is the hydrochloride salt of tivozanib, an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.
