Find verified Tenecteplase API manufacturers, suppliers, and distributors across the globe. Explore companies that offer high-purity Tenecteplase for pharmaceutical use, along with product details, certifications, and reliable sourcing options. Compare prices, check availability, and connect directly with trusted suppliers for Tenecteplase API.
Alternate Names: Tenecteplasa, tenecteplasum, TNK-tPA
CAS No: 191588-94-0
PubChem SID: 481101863
Mol Formula: C₂₅₆₁H₃₉₁₉N₇₄₇O₇₈₁S₄₀
Mol Weight: ~58,951 Da
IUPAC Name: N/A
API Description: Tenecteplase is a 527 amino acid glycoprotein and the modified form of the naturally occurring human plasminogen activator (tPA) with tissue plasminogen activating activity. Tenecteplase (TNKase) is a serine protease created by introducing substitutions of threonine 103 with asparagine, asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. TNKase converts fibrin-bound plasminogen to plasmin by cleaving the Arg/Val bond in plasminogen. Plasmin in turn degrades the fibrin matrix of the thrombus mass, thereby helps eliminate blood clots or arterial blockages that cause myocardial infarction.
