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Alternate Names: Butyric acid sodium salt, Butanoic acid, sodium salt
CAS No: 156-54-7
PubChem CID: 5222465
Mol Formula: C4H7NaO2
Mol Weight: 110.09 g/mol
IUPAC Name: sodium;butanoate
API Description: Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling.
