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Alternate Names: Siramesina, Siramesine free base
CAS No: 147817-50-3
PubChem CID: 9829526
Mol Formula: C30H31FN2O
Mol Weight: 454.6 g/mol
IUPAC Name: 1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine]
Commercial / Development Status: Discontinued APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: Siramesine, originally developed as an antidepressant, is now being investigated for its potential in cancer treatment due to its anti-tumor properties. It works by inducing cell death, particularly in cancer cells, through a process called lysosomal membrane permeabilization and ferroptosis. It has also shown promise in combination with other cancer drugs to overcome drug resistance.
