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Alternate Names: KW-6356
CAS No: 858979-50-7
PubChem CID: 23144148
Mol Formula: C20H19N3O4S
Mol Weight: 397.4 g/mol
IUPAC Name: N-[4-(furan-2-yl)-5-(oxane-4-carbonyl)-1,3-thiazol-2-yl]-6-methylpyridine-3-carboxamide
Commercial / Development Status: Discontinued APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: Sipagladenant (KW-6356) is an oral A2A adenosine receptor inverse agonist, investigated for cognitive and movement disorders like Parkinson's disease and frontal lobe dysfunction, showing promise in animal models for improving cognition and gait, but its development by Kyowa Kirin was discontinued despite early positive signs. It works by blocking adenosine A2A receptors, potentially increasing dopamine function, and is used in research settings for studying neurological conditions.
