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Alternate Names: L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, compd. with alpha-ethyl (alphaR,gammaS)-gamma-[(3-carboxy-1-oxopropyl)amino]-alpha-methyl[1,1'-biphenyl]-4-pentanoate (1:1)
CAS No: 1360873-85-3
PubChem CID: 24755620
Mol Formula: C48H58N6O8
Mol Weight: 847.0 g/mol
IUPAC Name: 4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid;(2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl -Show More
API Description: Sacubitril/valsartan is a combination medication used to treat heart failure with reduced ejection fraction (HFrEF). Sacubitril is a neprilysin inhibitor that increases levels of beneficial natriuretic peptides, promoting vasodilation and fluid excretion, while valsartan is an angiotensin II receptor blocker (ARB) that lowers blood pressure and reduces strain on the heart. Together, they improve heart function, reduce hospitalizations, and lower the risk of cardiovascular death in heart failure patients. It is marketed under the brand name Entresto.
