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Alternate Names: Sacubitril hemicalcium salt, AHU-377 calcium salt
CAS No: 1369773-39-6
PubChem CID: 92045585
Mol Formula: C48H56CaN2O10
Mol Weight: 861.0 g/mol
IUPAC Name: calcium;4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate
API Description: Sacubitril calcium is the calcium salt form of sacubitril, which is a prodrug and neprilysin inhibitor. It is used in combination with valsartan as a treatment for heart failure. Sacubitril is converted in the body to its active metabolite LBQ657, which inhibits neprilysin, an enzyme that degrades natriuretic peptides like atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), leading to vasodilation, natriuresis, and diuresis, which help lower blood pressure and reduce heart failure symptoms. Sacubitril calcium is orally bioavailable and studied mostly as part of the combination drug sacubitril/valsartan (brand name Entresto).
