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Alternate Names: Repaglinida, Repaglinidum, Surepost, Reglin
CAS No: 135062-02-1
Mol Formula: C27H36N2O4
Mol Weight: 452.6 g/mol
IUPAC Name: 2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)buty ]amino]-2-oxoethyl]benzoic acid - Show More
API Description: Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those naïve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Repaglinide is extensively metabolized in the liver and excreted in bile. Repaglinide metabolites do not possess appreciable hypoglycemic activity. Approximately 90% of a single orally administered dose is eliminated in feces and 8% in urine.
Apitoria Pharma Private Limited is a wholly owned subsidiary of Aurobindo Pharma Limited, established in 2023. It specializes in the manufacturing of Active Pharmaceutical Ingredients (APIs) and operates with a focus on agility, reliability, and innovation. The company offers a d verse portfolio of over 250 API molecules, including antibiotics, CNS & CVS drugs, antidiabetics, oncology products, and complex molecules. - Show More
Dr. Reddy's Laboratories Ltd. is an Indian multinational pharmaceutical company based in Hyderabad. The company was founded by Kallam Anji Reddy, who previously worked in the mentor institute Indian Drugs and Pharmaceuticals Limited. Dr. Reddy’s Lab manufactures and markets a w de range of pharmaceuticals in India and overseas. The company produces over 190 medications, 60 active pharmaceutical ingredients (APIs) for drug manufacture, diagnostic kits, critical care, and biotechnology. - Show More
The Boehringer Ingelheim group of companies objectives and believes can be summed up in a single phrase: Value through Innovation, the central concept of our corporate vision. Together with our corporate culture concept "Lead & Learn", this vision is the driver of our corporate c lture. Improving the health and quality of life of humans and animals is the goal of the research-driven pharmaceutical company Boehringer Ingelheim....The Boehringer Ingelheim group of companies objectives and believes can be summed up in a single phrase: Value through Innovation, the central concept of our corporate vision. Together with our corporate culture concept "Lead & Learn", this vision is the driver of our corporate culture. Improving the health and quality of life of humans and animals is the goal of the research-driven pharmaceutical company Boehringer Ingelheim. The focus in doing so is on diseases for which no satisfactory treatment option exists to date. - Show More
Zhejiang Hisoar Pharmaceutical Co., Ltd. is located in Taizhou, Zhejiang. It is an IPO-listed company held by the DanKong Group, which mainly manufactures APIs, Formulations, Fine Chemicals, Dyestuffs, and Dyestuff Intermediates. It is one of the top 100 innovative companies in t e national pharmaceutical industry. The main product categories are antibiotics, cardiovascular, hypoglycemic, and others, fine chemicals, formulatio...Zhejiang Hisoar Pharmaceutical Co., Ltd. is located in Taizhou, Zhejiang. It is an IPO-listed company held by the DanKong Group, which mainly manufactures APIs, Formulations, Fine Chemicals, Dyestuffs, and Dyestuff Intermediates. It is one of the top 100 innovative companies in the national pharmaceutical industry. The main product categories are antibiotics, cardiovascular, hypoglycemic, and others, fine chemicals, formulations, dyes, and intermediates. More than 70% of pharmaceutical products are exported, in which Clindamycin series production is in the leading position worldwide. - Show More
The word ‘Themis’ means – ‘that which is put in place’ and it is indeed the essence of our company, Themis Medicare, which ‘puts in place’ or integrates people, processes and potential towards the betterment of mankind. The company was promoted by Mr. Shantibhai D. atel, a pioneer in Indian Pharmaceuticals Business. Our founder's deep belief in the virtues of discipline and perfectionism has resonated clearly ...The word ‘Themis’ means – ‘that which is put in place’ and it is indeed the essence of our company, Themis Medicare, which ‘puts in place’ or integrates people, processes and potential towards the betterment of mankind. The company was promoted by Mr. Shantibhai D. Patel, a pioneer in Indian Pharmaceuticals Business. Our founder's deep belief in the virtues of discipline and perfectionism has resonated clearly within the organisation and even today is an integral part to our approach in all spheres such as operations and management, framing policy decisions, forging new alliances. - Show More
Jubilant Life Sciences Limited, is an integrated global pharmaceutical and life sciences company engaged in manufacture and supply of APIs, Solid Dosage Formulations, Radiopharmaceuticals, Allergy Therapy Products and Life Science Ingredients. It also provides services in Contrac Manufacturing of Sterile Injectables and Drug Discovery and Development. The Company’s strength lies in its unique offerings of Pharmaceutical and...Jubilant Life Sciences Limited, is an integrated global pharmaceutical and life sciences company engaged in manufacture and supply of APIs, Solid Dosage Formulations, Radiopharmaceuticals, Allergy Therapy Products and Life Science Ingredients. It also provides services in Contract Manufacturing of Sterile Injectables and Drug Discovery and Development. The Company’s strength lies in its unique offerings of Pharmaceutical and Life Sciences products and services across the value chain. Our success is an outcome of strategic focus on the pharmaceuticals and life sciences industry, moving up the pharmaceutical value chain for products. - Show More
Torrent Pharmaceuticals Ltd is a leading Indian multinational pharmaceutical company, part of the Torrent Group, headquartered in Ahmedabad, Gujarat. Founded in 1959 by U. N. Mehta (originally as Trinity Laboratories), Torrent Pharma is now among the top pharmaceutical companies n India and operates globally in more than 50 countries. - Show More
Macleods Pharmaceuticals Ltd. is a privately held, vertically integrated global pharmaceutical company headquartered in Mumbai, Maharashtra, India. Established in 1989, the company develops, manufactures, and markets a wide range of pharmaceutical formulations across major therap utic areas, including anti-infectives, cardiovascular, anti-diabetic, dermatology, and hormone treatments. - Show More
At Asymchem we are proud of the strides that we have made since our founding in 1999, providing R&D and one-stop production services to the world’s top pharmaceutical companies. Driving our success is our commitment to continual optimization and investing in the future. By impr ving the capabilities our partners need now, and maintaining the agility needed to support innovation, we’ve built a knowledge and experience base ...At Asymchem we are proud of the strides that we have made since our founding in 1999, providing R&D and one-stop production services to the world’s top pharmaceutical companies. Driving our success is our commitment to continual optimization and investing in the future. By improving the capabilities our partners need now, and maintaining the agility needed to support innovation, we’ve built a knowledge and experience base that we’re ready to share. - Show More
Biocon Limited is a leading Indian biopharmaceutical company headquartered in Bangalore, Karnataka. Founded in 1978 by Kiran Mazumdar-Shaw, Biocon has evolved into a global enterprise with a strong presence in over 120 countries.