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Alternate Names: Perhexilene, Perhexilina
CAS No: 6621-47-2
PubChem CID: 4746
Mol Formula: C19H35N
Mol Weight: 277.5 g/mol
IUPAC Name: 2-(2,2-dicyclohexylethyl)piperidine
Therapeutic use: Angina
Drug Class: Calcium Channel Blockers
Commercial / Development Status: Commercial APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: Perhexiline is a member of piperidines. It has a role as a cardiovascular drug. Perhexiline is a coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis. Perhexiline is only found in individuals that have used or taken this drug. It is a coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis. Perhexiline binds to the mitochondrial enzyme carnitine palmitoyltransferase (CPT)-1 and CPT-2. It acts by shifting myocardial substrate utilisation from long chain fatty acids to carbohydrates through inhibition of CPT-1 and, to a lesser extent, CPT-2, resulting in increased glucose and lactate utilization. This results in increased ATP production for the same O2 consumption as before and consequently increases myocardial efficiency. 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
