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Alternate Names: SU-5271 hydrochloride, AG 1517 hydrochloride
CAS No: 183322-45-4
PubChem CID: 11246488
Mol Formula: C16H15BrClN3O2
Mol Weight: 396.7 g/mol
IUPAC Name: N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride
Commercial / Development Status: Clinical APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: PD-153035 hydrochloride's primary use is as a highly specific inhibitor of the Epidermal Growth Factor Receptor (EGFR) tyrosine kinase, making it a tool for cancer research to study EGFR-driven cell proliferation and death. It is used in research settings to investigate the role of EGFR in various cellular processes and to develop treatments by inhibiting cancer cell growth and signaling in EGF receptor-overexpressing cells. It is also used in studies to improve glucose tolerance and insulin sensitivity in models of metabolic disorders.
