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Alternate Names: 5-azaorotic acid, Allantoxanic acid, Oxonate, Oxonsaure
CAS No: 937-13-3
PubChem CID: 4604
Mol Formula: C4H3N3O4
Mol Weight: 157.08 g/mol
IUPAC Name: 4,6-dioxo-1H-1,3,5-triazine-2-carboxylic acid
API Description: Oteracil is a modulator of 5-fluorouracil (5-FU) activity and inhibitor of the enzyme orotate phosphoribosyl-transferase (OPRT), with chemoprotective activity. Oteracil preferentially localizes in the gastrointestinal (GI) tract where it inhibits OPRT, thereby decreasing metabolism of 5-FU into its active metabolite 5-fluorouridine-5'-monophosphate (FUMP). This decreases activated 5-FU-related gastrointestinal toxicity.
