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Alternate Names: niraparibum, 2-(4-((3S)-piperidin-3-yl)phenyl)indazole-7-carboxamide
CAS No: 1038915-60-4
PubChem CID: 24958200
Mol Formula: C19H20N4O
Mol Weight: 320.4 g/mol
IUPAC Name: 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide
API Description: Niraparib is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy. It has a role as an antineoplastic agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a radiosensitizing agent and an apoptosis inducer.
