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Alternate Names: SDOLNFCUZATHSO-UHFFFAOYSA-N, Nilotinib monohydrochloride dihydrate
CAS No: 923289-71-8
PubChem CID: 67323320
Mol Formula: C28H27ClF3N7O3
Mol Weight: 602.0 g/mol
IUPAC Name: 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide;dihydrate;hydrochloride
API Description: Nilotinib hydrochloride dihydrate is the medically approved salt form of nilotinib, used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). It acts as a selective tyrosine kinase inhibitor, targeting the abnormal BCR-ABL protein that drives the uncontrolled growth of white blood cells in CML. This form improves the drug's solubility and stability, making it suitable for oral use in clinical settings, especially in patients resistant or intolerant to earlier treatments like imatinib.
