Find verified Mafodotin API manufacturers, suppliers, and distributors across the globe. Explore companies that offer high-purity Mafodotin for pharmaceutical use, along with product details, certifications, and reliable sourcing options. Compare prices, check availability, and connect directly with trusted suppliers for Mafodotin API.
Alternate Names: Maleimidocaproyl monomethylauristatin F, Auristatin F derivative
CAS No: 863971-19-1
PubChem CID: 56949327
Mol Formula: C49H76N6O11
Mol Weight: 925.20 g/mol
IUPAC Name: (2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoyl-methylamino]-3-methylbutanoyl]amino]-3-methylbutanoyl]-me -Show More
Commercial / Development Status: Unknown/Inactive APIs
Source / Manufacturing Origin: Peptide APIs
API Description: Mafodotin, referring to monomethyl auristatin F (MMAF) when employed as a cytotoxic payload in antibody–drug conjugates, is used to treat relapsed or refractory multiple myeloma. It serves as the potent toxic component in the ADC belantamab mafodotin (Blenrep), which targets B-cell maturation antigen (BCMA) on myeloma cells. Once internalized, the MMAF disrupts microtubule formation, induces cell cycle arrest, and triggers apoptotic death in malignant cells.
