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Alternate Names: UNII-94E9UR0RFR, NSC-800767
CAS No: 173529-46-9
PubChem CID: 9888590
Mol Formula: C22H20N2O5S
Mol Weight: 424.5 g/mol
IUPAC Name: N-(4-methoxyphenyl)sulfonyl-N-[2-[(E)-2-(1-oxidopyridin-1-ium-4-yl)ethenyl]phenyl]acetamide
API Description: HMN-214 is an N-sulfonylcarboxamide that is N-[(4-methoxyphenyl)sulfonyl]acetamide in which the hydrogen of the NH group is substituted by a 2-[(E)-2-(1-oxidopyridin-4-yl)ethenyl]phenyl group. It is a potent inhibitor of polo-like kinase 1 (PLK1) that exhibits antineoplastic activity. It has a role as an EC 2.7.11.21 (polo kinase) inhibitor, an antineoplastic agent, a prodrug and an apoptosis inducer. It is a monomethoxybenzene, a N-sulfonylcarboxamide, a member of pyridine N-oxides and an olefinic compound.
