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Alternate Names: GTS-21 dihydrochloride, DMXB-Anabaseine
CAS No: 148372-04-7
PubChem CID: 5310985
Mol Formula: C19H20N2O2
Mol Weight: 308.4 g/mol
IUPAC Name: 3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine
Commercial / Development Status: Discontinued
Source / Manufacturing Origin: Synthetic
API Description: GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive rights to the compound and a related library of analogs as part of the acquisition of Osprey Pharmaceutical Company in April 2006. GTS-21 has been studied in multiple Phase I studies in healthy volunteers and one Phase I/II study in schizophrenic patients. In all studies, the compound was well tolerated.
