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Alternate Names: Phosphotrienin, Pyranone phosphate, Fostriecinum
CAS No: 87810-56-8
PubChem CID: 6913994
Mol Formula: C19H27O9P
Mol Weight: 430.40 g/mol
IUPAC Name: [(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-1-[(2R)-6-oxo-2,3-dihydropyran-2-yl]trideca-1,7,9,11-tetraen-4-yl] dihydrogen phosphate
Commercial / Development Status: Discontinued
Source / Manufacturing Origin: Fermentation
API Description: Fostriecin is an anti-tumor antibiotic isolated from the bacterium Streptomyces pulveraceus. Fostriecin inhibits topoisomerase II catalytic activity, resulting in impaired DNA and RNA synthesis in various malignant cell types. This agent also inhibits serine/threonine protein phosphatase type 2A in some tumor cell types, thereby interfering with cellular proliferation and differentiation. (NCI04)
