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Alternate Names: Fosnetupitant chloride, Fosnetupitant dihydrochloride, Arokaris (TN)
CAS No: 1643757-72-5
PubChem CID: 86764535
Mol Formula: C31H37Cl2F6N4O5P
Mol Weight: 761.5 g/mol
IUPAC Name: [4-[5-[[2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl]-methylamino]-4-(2-methylphenyl)pyridin-2-yl]-1-methylpiperazin-1-ium-1-yl]methyl dihydro -Show More
API Description: Fosnetupitant Chloride Hydrochloride is the chloride hydrochloride salt form of fosnetupitant, a prodrug of netupitant, a selective neurokinin 1 receptor (NK1R; TACR1) antagonist, with potential antiemetic activity. Upon intravenous administration, fosnetupitant is converted by phosphatases to its active form netupitant. Netupitant competitively binds to and blocks the activity of NK1Rs in the central nervous system (CNS), by inhibiting binding of the endogenous tachykinin-derived neuropeptide substance P (SP) to NK1R. This prevents delayed emesis, which is associated with SP secretion. This may prevent chemotherapy-induced nausea and vomiting
