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Alternate Names: ensifentrinum, Ohtuvayre
CAS No: 1884461-72-6
PubChem CID: 9934746
Mol Formula: C26H31N5O4
Mol Weight: 477.6 g/mol
IUPAC Name: 2-[9,10-dimethoxy-4-oxo-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[6,1-a]isoquinolin-3-yl]ethylurea
API Description: Ensifentrine is a novel, potent, and selective dual inhibitor of phosphodiesterase (PDE) 3 and PDE4 designed for inhalation treatment, primarily for chronic obstructive pulmonary disease (COPD). It combines bronchodilator, anti-inflammatory, and ciliary function-enhancing effects in the lungs, improving airway function and reducing symptoms such as wheezing, shortness of breath, and chest tightness. Ensifentrine is marketed under the brand name Ohtuvayre and was approved in the United States in June 2024 for maintenance treatment of COPD in adults.