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Alternate Names: Carboprostum, Methyl-pgf2-alpha, Prostin 15M
CAS No: 35700-23-3
PubChem CID: 5281075
Mol Formula: C21H36O5
Mol Weight: 368.5 g/mol
IUPAC Name: (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-3-methyloct-1-enyl]cyclopentyl]hept-5-enoic acid
Drug Class: Prostaglandins, Vasoconstrictors
Commercial / Development Status: Commercial APIs
Source / Manufacturing Origin: Semi-synthetic APIs
API Description: Carboprost is the (15S)-15 methyl analogue of naturally occurring prostaglandin F2 alpha (PGF2 alpha) with oxytocic activity. Mimicking endogenous PGF2 alpha, carboprost activates prostaglandin F receptor, a G-protein coupled receptor, on smooth muscle cells, thereby resulting in smooth muscle contractions. When administered intramuscularly on gravid subjects, this agent induces myometrium contractions, thereby initiating luteolysis and consequently parturition. Furthermore, carboprost's action on vascular smooth muscle and gastrointestinal tract sphincters leads to raised blood pressure and induces vomiting or diarrhea, respectively.
