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Alternate Names: capmatinibum, INC-280
CAS No: 1029712-80-8
PubChem CID: 25145656
Mol Formula: C23H17FN6O
Mol Weight: 412.4 g/mol
IUPAC Name: 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
Therapeutic use: Anti-cancer agents
Drug Class: Kinase inhibitors
Commercial / Development Status: Commercial APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: Capmatinib is a member of the class of imidazotriazines that is imidazo[1,2-b][1,2,4]triazine substituted by 3-fluoro-4-(methylcarbamoyl)phenyl and quinolin-6-ylmethyl groups at positions 2 and 7, respectively. It is a c-Met receptor tyrosine kinase inhibitor used for the treatment of non-small cell lung cancer with MET exon 14 skipping mutation. It has a role as a c-Met tyrosine kinase inhibitor, an antineoplastic agent, a hepatotoxic agent and an apoptosis inducer. It is a member of quinolines, a member of monofluorobenzenes, a member of benzamides, a secondary carboxamide and an imidazotriazine.
