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Alternate Names: Butethal, Butobarbitone, Butobarbitural, Soneryl
CAS No: 77-28-1
PubChem CID: 6473
Mol Formula: C10H16N2O3
Mol Weight: 212.25 g/mol
IUPAC Name: 5-butyl-5-ethyl-1,3-diazinane-2,4,6-trione
Drug Class: Barbiturates
Commercial / Development Status: Discontinued APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: Butobarbital is a member of barbiturates. Butobarbital is a sedative and a hypnotic drug. Butethal is only found in individuals that have used or taken this drug. It is a sedative and a hypnotic drug.Butethal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission. Butobarbital should be distinguished from Butabarbital (a synonym for Secbutabarbital)
