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Alternate Names: 1-Butylbiguanide, Buformine, Butylbiguanide, Butyldiguanide
CAS No: 692-13-7
PubChem CID: 2468
Mol Formula: C6H15N5
Mol Weight: 157.22 g/mol
IUPAC Name: 2-butyl-1-(diaminomethylidene)guanidine
Therapeutic use: Antidiabetic agents
Drug Class: Biguanides
Commercial / Development Status: Discontinued APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: Buformin is a member of the class of biguanides that is biguanide substituted by a butyl group at position 1. It is an antidiabetic drug with potential antitumor effect. It has a role as a radiosensitizing agent, a geroprotector, an antiviral agent, a hypoglycemic agent and an antineoplastic agent. It is functionally related to a biguanide. Buformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of causing lactic acidosis. Buformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. Buformin is not metabolized and is excreted in the urine. This agent has been withdrawn from the market due to its elevated risk of lactic acidosis. An oral hypoglycemic agent that inhibits gluconeogenesis, increases glycolysis, and decreases glucose oxidation.
