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Alternate Names: Bromfenac sodium hydrate, Xibrom, Prolensa, AHR-10282B, DTXSID8044206
CAS No: 120638-55-3
PubChem CID: 11954316
Mol Formula: C30H28Br2N2Na2O9
Mol Weight: 766.3 g/mol
IUPAC Name: disodium;2-[2-amino-3-(4-bromobenzoyl)phenyl]acetate;trihydrate
API Description: Bromfenac Sodium is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure
