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Alternate Names: Ayvakit
CAS No: 1703793-34-3
PubChem CID: 118023034
Mol Formula: C26H27FN10
Mol Weight: 498.6 g/mol
IUPAC Name: (1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine
API Description: Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis. It is one of the first medications available for the treatment of multidrug resistant cancers. Avapritinib shares a similar mechanism with ripretinib. Avapritinib was granted FDA approval on 9 January 2020 and EMA approval on 24 September 2020.
