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Alternate Names: Atenolol monoacetate, Atenolol ethanolate
CAS No: 250579-95-4
PubChem CID: 551861
Mol Formula: C16H24N2O4
Mol Weight: 308.37 g/mol
IUPAC Name: [1-[4-(2-amino-2-oxoethyl)phenoxy]-3-(propan-2-ylamino)propan-2-yl] acetate
API Description: Atenolol acetate is a derivative of atenolol, a widely used selective β₁-adrenergic receptor blocker prescribed for conditions such as hypertension, angina, and post-myocardial infarction care. Atenolol acetate is typically synthesized through enzymatic or chemical acetylation of atenolol. For instance, lipase-catalyzed kinetic resolution has been employed to produce enantiomerically pure (S)-atenolol acetate. This method utilizes Candida rugosa lipase and isopropenyl acetate as the acetylating agent, achieving high enantiomeric excess (ee) values.
