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Alternate Names: aminophenazone, Eufibron, 4-Dimethylaminoantipyrine, Itamidone, Dereuma, Febron
CAS No: 58-15-1
PubChem CID: 6009
Mol Formula: C13H17N3O
Mol Weight: 231.29 g/mol
IUPAC Name: 4-(dimethylamino)-1,5-dimethyl-2-phenylpyrazol-3-one
Therapeutic use: Analgesics
Commercial / Development Status: Discontinued APIs
Source / Manufacturing Origin: Synthetic APIs
API Description: Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic properties that carries a risk of agranulocytosis. In biomedical applications, radiolabelled (13C-labeled) aminophenazone has been used in breath tests to measure the cytochrome P-450 metabolic activity in liver function tests. The FDA suspended the use of aminophenazone due to its association with agranulocytosis, a life-threatening side effect. Aminophenazone is a pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, an environmental contaminant and a xenobiotic. It is a tertiary amino compound and a pyrazolone.
