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Alendronate Sodium API Suppliers - Manufacturers and Distributors

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Alendronate Sodium

Alternate Names: Alendronate monosodium trihydrate, Alendronate sodium trihydrate, Alendronate sodium hydrate

CAS No: 121268-17-5

Mol Formula: C4H18NNaO10P2

Mol Weight: 325.12 g/mol

IUPAC Name: sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate;trihydrate

API Description: Alendronate Sodium is a bisphosphonate that inhibits osteoclast-mediated bone resorption, used to treat osteoporosis and Paget's disease of bone. Alendronate Sodium is the sodium salt of alendronate, a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced. Alendronate sodium trihydrate is a hydride that is the trihydrate of alendronate sodium It has a role as a bone density conservation agent and an EC 2.5.1.1 (dimethylallyltranstransferase) inhibitor. It is an organic sodium salt and a hydrate. It contains an alendronate(1-). ChEBI

                   
Alendronate Sodium

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