Tert-butyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)morpholine-4-carboxylate (CAS No: 2641824-60-2) is a key pharmaceutical intermediate used in the synthesis of APIs Zoldonrasib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Methyl (S)-3-[(S)-4-Boc-morpholin-2-yl]-2-(Cbz-amino)propanoate, Tert-butyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)morpholine-4-carboxylate
CAS No: 2641824-60-2
PubChem CID: 156679026
Mol Formula: C21H30N2O7
Mol Weight: 422.5 g/mol
Used in API: Zoldonrasib
IUPAC Name: tert-butyl (2S)-2-[(2S)-3-methoxy-3-oxo-2-(phenylmethoxycarbonylamino)propyl]morpholine-4-carboxylate
API Intermediate Description: Zoldonrasib (RMC-9805) is a selective KRAS G12D inhibitor, and tert-butyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)morpholine-4-carboxylate is a protected chiral amino-acid/morpholine intermediate used in its synthesis. It contains Boc- and Cbz-protected nitrogen functionalities that enable selective downstream transformations while preserving the required stereochemistry. Subsequent deprotection, coupling, and functional-group transformations allow this intermediate to contribute to the advanced molecular framework leading to the final zoldonrasib API.
