tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate (CAS No: 236406-49-8) is a key pharmaceutical intermediate used in the synthesis of APIs Zoldonrasib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 2-Boc-2,7-diazaspiro[4.4]nonane, 2,7-Diazaspiro[4.4]nonane-2-carboxylic acid tert-butyl ester
CAS No: 236406-49-8
PubChem CID: 23282813
Mol Formula: C12H22N2O2
Mol Weight: 226.32 g/mol
Used in API: Zoldonrasib
IUPAC Name: tert-butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate
API Intermediate Description: Zoldonrasib (RMC-9805) is a selective KRAS G12D inhibitor, and tert-butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate is a protected spirocyclic diamine intermediate used in its synthesis. The Boc-protected diazaspiro[4.4]nonane provides an important chiral/amine-containing structural building block, with the protected nitrogen allowing selective downstream coupling and functionalization. Subsequent deprotection and coupling reactions incorporate this spirocyclic unit into advanced intermediates that lead to the final zoldonrasib API.
![tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate](https://apicule.com/wp-content/uploads/apis/2dc8570edf18e0e49fc5ae906fbf2ccf.png)
