(S)-2-((S)-7-(tert-butoxycarbonyl)-2,7-diazaspiro[4.4]nonan-2-yl)-2-cyclopentylacetic acid (CAS No: 2865128-45-4) is a key pharmaceutical intermediate used in the synthesis of APIs Zoldonrasib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: (S)-2-[(S)-7-Boc-2,7-diazaspiro[4.4]nonan-2-yl]-2-cyclopentylacetic Acid
CAS No: 2865128-45-4
PubChem CID: 166116241
Mol Formula: C19H32N2O4
Mol Weight: 352.5 g/mol
Used in API: Zoldonrasib
IUPAC Name: (2S)-2-cyclopentyl-2-[(5S)-2-[(2-methylpropan-2-yl)oxycarbonyl]-2,7-diazaspiro[4.4]nonan-7-yl]acetic acid
API Intermediate Description: Zoldonrasib (RMC-9805) is a selective KRAS G12D inhibitor, and (S)-2-((S)-7-(tert-butoxycarbonyl)-2,7-diazaspiro[4.4]nonan-2-yl)-2-cyclopentylacetic acid is an advanced chiral intermediate used in its synthesis. It contains the Boc-protected diazaspiro[4.4]nonane core and cyclopentylacetic acid moiety, providing important structural and stereochemical features for subsequent amide-coupling reactions. Further deprotection and coupling with other advanced fragments contribute to assembly of the final zoldonrasib API.
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