N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide (CAS No: 1139453-98-7) is a key pharmaceutical intermediate used in the synthesis of APIs Nintedanib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: N,4-Dimethyl-N-(4-nitrophenyl)-1-piperazineacetamide, 1-Piperazineacetamide, N,4-dimethyl-N-(4-nitrophenyl)-
CAS No: 1139453-98-7
PubChem CID: 23507600
Mol Formula: C14H20N4O3
Mol Weight: 292.33 g/mol
Used in API: Nintedanib
IUPAC Name: N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide
API Intermediate Description: N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide is a crucial precursor (intermediate) in the synthesis of Nintedanib; it is often formed by reacting N-methyl-4-nitroaniline with chloroacetyl chloride and then N-methylpiperazine, and it's subsequently converted to the amino-derivative (N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide) by reducing the nitro group, which then couples with the indolinone part to form Nintedanib.
