Methyl 4-(4-chloro-1-oxobutyl)-alpha,alpha-dimethylbenzeneacetate (CAS No: 154477-54-0) is a key pharmaceutical intermediate used in the synthesis of APIs Fexofenadine hydrochloride. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 2-[4-(4-Chloro-butyryl)-phenyl]-2-methyl-propionic acid methyl ester, Methyl 2-[4-(4-chlorobutanoyl)phenyl]-2-methyl-propanoate
CAS No: 154477-54-0
PubChem CID: 10062338
Mol Formula: C15H19ClO3
Mol Weight: 282.76 g/mol
Used in API: Fexofenadine hydrochloride
IUPAC Name: methyl 2-[4-(4-chlorobutanoyl)phenyl]-2-methylpropanoate
API Intermediate Description: Methyl 4-(4-chloro-1-oxobutyl)-α,α-dimethylbenzeneacetate is used as an important aryl-ketone intermediate in the synthesis of Fexofenadine Hydrochloride. The chloro-butyl side chain undergoes nucleophilic substitution with a suitable piperidine derivative, forming the key carbon–nitrogen bond required for the antihistamine structure. Subsequent hydrolysis and functional group modifications convert the ester and ketone functionalities to produce the final active drug, Fexofenadine Hydrochloride.
