Methyl 3-hydroxy-4-methoxybenzoate (CAS No: 6702-50-7) is a key pharmaceutical intermediate used in the synthesis of APIs Gefitinib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Methyl isovanillate, Methyl 3-hydroxy-4-methoxybenzenecarboxylate
CAS No: 6702-50-7
PubChem CID: 4056967
Mol Formula: C9H10O4
Mol Weight: 182.17 g/mol
Used in API: Gefitinib
IUPAC Name: methyl 3-hydroxy-4-methoxybenzoate
API Intermediate Description: Methyl 3‑hydroxy‑4‑methoxybenzoate is a key intermediate in the synthesis of the anticancer active pharmaceutical ingredient Gefitinib. In its synthetic pathway, this compound provides the substituted benzoate fragment that is elaborated through a series of reactions, including alkylation, nitration, reduction, cyclization, and amination, to construct the quinazoline core essential for Gefitinib’s activity. Through these transformations, the intermediate is converted into the final API, which functions as a tyrosine kinase inhibitor used in the treatment of non‑small cell lung cancer (NSCLC).
