Lithium (2R,3R)-3-Cyclopropyl-1-methylaziridine-2-carboxylate (CAS No: 2864383-31-1) is a key pharmaceutical intermediate used in the synthesis of APIs Zoldonrasib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 2-Aziridinecarboxylic acid, 3-cyclopropyl-1-methyl-, lithium salt (1:1), (2R,3R)-, Lithium(2R,3R)-3-cyclopropyl-1-methylaziridine-2-carboxylat
CAS No: 2864383-31-1
PubChem CID: 168201436
Mol Formula: C7H10LiNO2
Mol Weight: 147.1 g/mol
Used in API: Zoldonrasib
IUPAC Name: lithium (2R,3R)-3-cyclopropyl-1-methylaziridine-2-carboxylate
API Intermediate Description: Zoldonrasib (RMC-9805) is a selective KRAS G12D inhibitor, and lithium (2R,3R)-3-cyclopropyl-1-methylaziridine-2-carboxylate is a chiral aziridine carboxylate intermediate used in its synthesis. It provides a stereochemically defined aziridine–cyclopropyl building block, while the lithium carboxylate enables further coupling and functional-group transformations. Subsequent reactions of this intermediate help introduce the required chiral structural features into advanced intermediates leading to the zoldonrasib API.
