6-Bromo-2-chloro-8-cyclopentyl-5-methyl-8H-pyrido(2,3-d)pyrimidin-7-one (CAS No: 1016636-76-2) is a key pharmaceutical intermediate used in the synthesis of APIs Palbociclib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-bromo-2-chloro-8-cyclopentyl-5-methyl-, palbociclib intermediate
CAS No: 1016636-76-2
PubChem CID: 44248249
Mol Formula: C13H13BrClN3O
Mol Weight: 342.62 g/mol
Used in API: Palbociclib
IUPAC Name: 6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one
API Intermediate Description: 6-Bromo-2-chloro-8-cyclopentyl-5-methyl-8H-pyrido(2,3-d)pyrimidin-7-one is a crucial intermediate in the synthesis of Palbociclib (PD 0332991), a CDK4/6 inhibitor used for treating breast cancer. It serves as a key core structure, typically produced by cyclizing 1-(2,4-dichloropyrimidin-5-yl)ethanone with cyclopentylamine, followed by cyclization and bromination.
