5-Bromo-2,4-dichloropyrimidine (CAS No: 36082-50-5) is a key pharmaceutical intermediate used in the synthesis of APIs Palbociclib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Palbociclib impurity 99, 2,6-dichloro-5-bromopyrimidine
CAS No: 36082-50-5
PubChem CID: 289973
Mol Formula: C4HBrCl2N2
Mol Weight: 227.87 g/mol
Used in API: Palbociclib
IUPAC Name: 5-bromo-2,4-dichloropyrimidine
API Intermediate Description: 5-Bromo-2,4-dichloropyrimidine is a crucial, high-yield starting material for synthesizing Palbociclib (a CDK4/6 inhibitor) intermediates. It is used to prepare the pyridopyrimidine core, specifically through reactions involving 5-bromo-2-chloro-N-cyclopentylpyrimidin-4-amine to form 2-chloro-8-cyclopentyl-5-methylpyrido[3-d]pyrimidin-7(8H)-one.
