5-Bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine (CAS No: 733039-20-8) is a key pharmaceutical intermediate used in the synthesis of APIs Palbociclib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Palbociclib Impurity 31, 4-Pyrimidinamine, 5-bromo-2-chloro-N-cyclopentyl-
CAS No: 733039-20-8
PubChem CID: 44248247
Mol Formula: C9H11BrClN3
Mol Weight: 276.56 g/mol
Used in API: Palbociclib
IUPAC Name: 5-bromo-2-chloro-N-cyclopentylpyrimidin-4-amine
API Intermediate Description: 5-Bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine is an important synthetic intermediate used in the manufacture of Palbociclib. It functions as a key substituted pyrimidine building block in the stepwise construction of the palbociclib core structure. The presence of both bromo and chloro substituents on the pyrimidine ring allows for selective palladium-catalyzed cross-coupling reactions, such as Suzuki or Buchwald–Hartwig coupling, enabling the introduction of the required heterocyclic and aromatic moieties. The N-cyclopentyl group is retained as part of the final molecular structure, contributing to the pharmacologically active scaffold. Thus, this compound plays a critical role in assembling the kinase-inhibiting framework characteristic of palbociclib.
