4-(4-Aminophenoxy)-N-methylpicolinamide (CAS No: 284462-37-9) is a key pharmaceutical intermediate used in the synthesis of APIs Sorafenib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Sorafenib impurity A, 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl-
CAS No: 284462-37-9
PubChem CID: 16655129
Mol Formula: C13H13N3O2
Mol Weight: 243.26 g/mol
Used in API: Sorafenib
IUPAC Name: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
API Intermediate Description: 4-(4-Aminophenoxy)-N-methylpicolinamide (APNMP) is primarily used as a key pharmaceutical intermediate in medicinal chemistry, especially for synthesizing anticancer drugs, notably sorafenib (Nexavar) and its structural analogs, by targeting protein kinases like Raf kinase and MET protein to inhibit cancer cell growth and proliferation. It also serves as an analytical standard, a tracer (deuterated form), and a building block in organic synthesis for developing new targeted therapies and studying biological pathways.
