(3R,4S,5R,6R)-3,4,5-Tris-trimethylsilanyloxy-6-trimethylsilanyloxymethyl-tetrahydro-pyran-2-on (CAS No: 32384-65-9) is a key pharmaceutical intermediate used in the synthesis of APIs Canagliflozin, Dapagliflozin and Empagliflozin. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 2,3,4,6-tetrakis-o-trimethylsilyl-d-gluconolactone, Gluconic acid lactone, TMS # 1
CAS No: 32384-65-9
PubChem CID: 10994280
Mol Formula: C18H42O6Si4
Mol Weight: 466.9 g/mol
Used in APIs: Canagliflozin, Dapagliflozin and Empagliflozin
IUPAC Name: (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-(trimethylsilyloxymethyl)oxan-2-one
API Intermediate Description: (3R,4S,5R,6R)-3,4,5-Tris-trimethylsilanyloxy-6-trimethylsilanyloxymethyl-tetrahydro-pyran-2-on is primarily used as a chemical intermediate in the synthesis of pharmaceuticals, most notably the SGLT2 inhibitors Canagliflozin and Dapagliflozin, which are used to treat type 2 diabetes. It can also be used in research settings for developing analytical methods or as a reference standard.
