(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine, hemi((2R,3R)-2,3-bis((4-methylbenzoyl)oxy)succinate) (CAS No: 477600-71-8) is a key pharmaceutical intermediate used in the synthesis of APIs Tofacitinib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Bis[(3R,4R)-N,4-dimethyl-1-(phenylmethyl)-3-piperidinamine] di-p-toluyl-L-tartrate, (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine hemi-di-p-toluoyl-L-tartrate
CAS No: 477600-71-8
PubChem CID: 67295176
Mol Formula: C48H62N4O8
Mol Weight: 823.0 g/mol
Used in API: Tofacitinib
IUPAC Name: bis((3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine);(2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid
API Intermediate Description: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine, hemi((2R,3R)-2,3-bis((4-methylbenzoyl)oxy)succinate) is a complex chiral pharmaceutical intermediate (salt form) used in multi-step organic synthesis. It contains a piperidine amine core with benzyl and dimethyl substitutions, along with a hemi-succinate salt derived from a protected tartaric/succinate-type acid, which helps improve crystallization and handling. Such structures are typically used in the preparation of advanced intermediates or APIs where stereochemistry is critical.
