(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine (CAS No: 477600-70-7) is a key pharmaceutical intermediate used in the synthesis of APIs Tofacitinib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: cis-1-Benzyl-N,4-dimethylpiperidin-3-amine, Tofacitinib Related Impurity 7
CAS No: 477600-70-7
PubChem CID: 44630604
Mol Formula: C14H22N2
Mol Weight: 218.34 g/mol
Used in API: Tofacitinib
IUPAC Name: (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine
API Intermediate Description: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine is a critical chiral intermediate used in the synthesis of the JAK inhibitor Tofacitinib (CP-690,550). It provides the required (3R, 4R)-stereochemistry for the piperidine moiety, which is subsequently reacted with 4-chloro-7H-pyrrolo[3-d]pyrimidine, followed by debenzylation and acetylation to produce Tofacitinib citrate.
