3-Piperidinamine, N,4-dimethyl-1-(phenylmethyl)-, hydrochloride (1:2) (CAS No: 1228879-37-5) is a key pharmaceutical intermediate used in the synthesis of APIs Tofacitinib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: 1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride, 1-Benzyl-4-methyl-3-(methylamino)piperidine Dihydrochloride
CAS No: 1228879-37-5
PubChem CID: 9943888
Mol Formula: C14H24Cl2N2
Mol Weight: 291.3 g/mol
Used in API: Tofacitinib
IUPAC Name: 1-benzyl-N,4-dimethylpiperidin-3-amine;dihydrochloride
API Intermediate Description: 3-Piperidinamine, N,4-dimethyl-1-(phenylmethyl)-, hydrochloride (1:2) acts as a critical intermediate in the synthesis of Tofacitinib. It serves as the precursor to the chiral piperidine core, where the N-benzyl group is removed via hydrogenation to allow N-acylation, providing the 3-aminopiperidine moiety essential for Tofacitinib's structure.
