3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (CAS No: 641571-11-1) is a key pharmaceutical intermediate used in the synthesis of APIs Nilotinib. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Benzenamine, 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-;, 1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole
CAS No: 641571-11-1
PubChem CID: 12002825
Mol Formula: C11H10F3N3
Mol Weight: 241.21 g/mol
Used in API: Nilotinib
IUPAC Name: 3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)aniline
API Intermediate Description: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline is an important intermediate in the synthesis of Nilotinib, functioning as the aryl amine component that couples with the previously constructed pyrimidine-pyridine-benzoic acid fragment. The amino group on this intermediate participates in a nucleophilic aromatic substitution or amide/urea-type coupling, forming a key bond that connects the imidazole-trifluoromethyl-substituted phenyl ring to the central scaffold of Nilotinib. The trifluoromethyl group and methyl-imidazole confer both lipophilicity and electronic effects, enhancing binding to the ATP-binding site of BCR-ABL while maintaining selectivity. In short, this intermediate is essential for introducing the hydrophobic and heterocyclic moieties that are critical for the drug’s potent kinase inhibition.
