2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester (CAS No: 74936-72-4) is a key pharmaceutical intermediate used in the synthesis of APIs Lercanidipine. This compound serves as an essential raw material in API development and synthesis. Explore detailed chemical properties, molecular data, structure information, and verified global suppliers, manufacturers, and distributors of this API intermediate on apicule.
Alternate Names: Carboxy-nifedipine, 1,4-Dihydro-2,6-dimethyl-4--(3-nitrophenyl)pyridine-3-carboxylic acid-5-carboxylic methyl ester
CAS No: 74936-72-4
PubChem CID: 173322
Mol Formula: C16H16N2O6
Mol Weight: 332.31 g/mol
Used in API: Lercanidipine
IUPAC Name: 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid
API Intermediate Description: The compound 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester serves as a crucial intermediate precursor in synthesizing Lercanidipine, a calcium channel blocker; it's typically modified by converting the remaining carboxylic acid into a specific amino-alcohol side chain (like 2-(1-benzyl-3-piperidyl)ethanol derivative) via activation (e.g., to an acid chloride) and subsequent coupling, leading to the final Lercanidipine molecule, demonstrating its role in building the complex dihydropyridine structure.
